Each post is a discovery. IRDME is the method — the finding is the story. All results link to their pre-registered hash.
FPL holds in 79,554 mouse V1 cortex neurons (r=+0.455, p=0) -- first mammalian confirmation. But the insect scaling trend (0.317 to 0.819 across 428x) does not extend to mammals. Mouse cortex with 79k neurons gives weaker FPL than larval Drosophila with 2,952. Brain architecture matters more than neuron count.
The Functional Proximity Law holds at 129,117 neurons in the adult Drosophila connectome (r=+0.819) -- the strongest confirmation ever measured. Global inhibition is the structural backbone, dopamine neurons are universal hubs, and FPL strengthens monotonically across a 428x scale range.
Pre-registered cross-species FPL replication in the Drosophila larval connectome (n=2952 neurons, Winding et al. 2023): h1 CONFIRMED Pearson r=0.363 / Spearman rho=0.663, p=0.002. Hub rank order conserved across 600 million years of evolution. Spearman >> Pearson discrepancy is the primary finding. 25/31 pre-registered, p=0.000439.
F12 pre-registered result: the Functional Proximity Law holds across the full C. elegans 302-neuron connectome (n=279 with synapses). 13 of 15 command interneurons from the smaller M_EXT2 study appear in the top-20 hubs — hub identity preserved at 20:1 scale compression.
The C. elegans connectome experiment uses topology alone to identify PVCL and PVCR as primary command interneurons. r = 0.7774, p = 0.004. The layer definitions and node rankings come from White et al. 1986 — fully independent of IRDME. This is true external validation.